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Crystal structures, absolute configurations and molecular docking studies of naftopidil enantiomers as α(1D)-adrenoceptor antagonists

Chiral drug naftopidil (NAF), a specific α(1D)-adrenoceptor (AR) antagonist for the treatment of benign prostatic hyperplasia, was used in racemic form for several decades. Our recent work declared that NAF enantiomers showed the same antagonistic effects on the α(1D)-AR, but the binding mechanism o...

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Dettagli Bibliografici
Pubblicato in:Acta Pharm Sin B
Autori principali: Xu, Wei, Huang, Junjun, Jiang, Renwang, Yuan, Mu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518653/
https://ncbi.nlm.nih.gov/pubmed/28752036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2017.04.011
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