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Crystal structures, absolute configurations and molecular docking studies of naftopidil enantiomers as α(1D)-adrenoceptor antagonists
Chiral drug naftopidil (NAF), a specific α(1D)-adrenoceptor (AR) antagonist for the treatment of benign prostatic hyperplasia, was used in racemic form for several decades. Our recent work declared that NAF enantiomers showed the same antagonistic effects on the α(1D)-AR, but the binding mechanism o...
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| Publicado no: | Acta Pharm Sin B |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5518653/ https://ncbi.nlm.nih.gov/pubmed/28752036 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2017.04.011 |
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