TCR-ligand dissociation rate is a robust and stable biomarker of CD8(+) T cell potency

Despite influencing many aspects of T cell biology, the kinetics of T cell receptor (TCR) binding to peptide-major histocompatibility molecules (pMHC) remain infrequently determined in patient monitoring or for adoptive T cell therapy. Using specifically designed reversible fluorescent pMHC multimer...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Allard, Mathilde, Couturaud, Barbara, Carretero-Iglesia, Laura, Duong, Minh Ngoc, Schmidt, Julien, Monnot, Gwennaëlle C., Romero, Pedro, Speiser, Daniel E., Hebeisen, Michael, Rufer, Nathalie
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518551/
https://ncbi.nlm.nih.gov/pubmed/28724801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92570
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