High Peptide Dose Vaccination Promotes the Early Selection of Tumor Antigen-Specific CD8 T-Cells of Enhanced Functional Competence

CD8 T-cell response efficiency critically depends on the TCR binding strength to peptide-MHC, i.e., the TCR binding avidity. A current challenge in onco-immunology lies in the evaluation of vaccine protocols selecting for tumor-specific T-cells of highest avidity, offering maximal immune protection...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Carretero-Iglesia, Laura, Couturaud, Barbara, Baumgaertner, Petra, Schmidt, Julien, Maby-El Hajjami, Hélène, Speiser, Daniel E., Hebeisen, Michael, Rufer, Nathalie
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6960191/
https://ncbi.nlm.nih.gov/pubmed/31969886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.03016
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