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Selective binding of ligands to beta 1, beta 2 or chimeric beta 1/beta 2-adrenergic receptors involves multiple subsites.

The molecular basis of ligand binding selectivity to beta-adrenergic receptor subtypes was investigated by designing chimeric beta 1/beta 2-adrenergic receptors. These molecules consisted of a set of reciprocal constructions, obtained by the exchange between the wild-type receptor genes of one to th...

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Detalles Bibliográficos
Publicado en:EMBO J
Principais autores: Marullo, S, Emorine, L J, Strosberg, A D, Delavier-Klutchko, C
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 1990
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC551837/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1970295/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1990.tb08264.x
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