Selective binding of ligands to beta 1, beta 2 or chimeric beta 1/beta 2-adrenergic receptors involves multiple subsites.

The molecular basis of ligand binding selectivity to beta-adrenergic receptor subtypes was investigated by designing chimeric beta 1/beta 2-adrenergic receptors. These molecules consisted of a set of reciprocal constructions, obtained by the exchange between the wild-type receptor genes of one to th...

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Pubblicato in:	EMBO J
Autori principali:	Marullo, S, Emorine, L J, Strosberg, A D, Delavier-Klutchko, C
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 1990
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC551837/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1970295/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1990.tb08264.x
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