An Iterative Module in the Azalomycin F Polyketide Synthase Contains a Switchable Enoylreductase Domain

Detailed analysis of the modular Type I polyketide synthase (PKS) involved in the biosynthesis of the marginolactone azalomycin F in mangrove Streptomyces sp. 211726 has shown that only nineteen extension modules are required to accomplish twenty cycles of polyketide chain elongation. Analysis of th...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Xu, Wei, Zhai, Guifa, Liu, Yuanzhen, Li, Yuan, Shi, Yanrong, Hong, Kui, Hong, Hui, Leadlay, Peter F., Deng, Zixin, Sun, Yuhui
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518293/
https://ncbi.nlm.nih.gov/pubmed/28418225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201701220
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