Pyrimethamine significantly lowers cerebrospinal fluid Cu/Zn superoxide dismutase in amyotrophic lateral sclerosis patients with SOD1 mutations

OBJECTIVE: Cu/Zn superoxide dismutase (SOD1) reduction prolongs survival in SOD1‐transgenic animal models. Pyrimethamine produces dose‐dependent SOD1 reduction in cell culture systems. A previous phase 1 trial showed pyrimethamine lowers SOD1 levels in leukocytes in patients with SOD1 mutations. Thi...

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Detaylı Bibliyografya
Yayımlandı:Ann Neurol
Asıl Yazarlar: Lange, Dale J., Shahbazi, Mona, Silani, Vincenzo, Ludolph, Albert C., Weishaupt, Jochen H., Ajroud‐Driss, Senda, Fields, Kara G., Remanan, Rahul, Appel, Stanley H., Morelli, Claudia, Doretti, Alberto, Maderna, Luca, Messina, Stefano, Weiland, Ulrike, Marklund, Stefan L., Andersen, Peter M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2017
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518287/
https://ncbi.nlm.nih.gov/pubmed/28480639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24950
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