Pyrimethamine significantly lowers cerebrospinal fluid Cu/Zn superoxide dismutase in amyotrophic lateral sclerosis patients with SOD1 mutations

OBJECTIVE: Cu/Zn superoxide dismutase (SOD1) reduction prolongs survival in SOD1‐transgenic animal models. Pyrimethamine produces dose‐dependent SOD1 reduction in cell culture systems. A previous phase 1 trial showed pyrimethamine lowers SOD1 levels in leukocytes in patients with SOD1 mutations. Thi...

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Publicado en:Ann Neurol
Autores principales: Lange, Dale J., Shahbazi, Mona, Silani, Vincenzo, Ludolph, Albert C., Weishaupt, Jochen H., Ajroud‐Driss, Senda, Fields, Kara G., Remanan, Rahul, Appel, Stanley H., Morelli, Claudia, Doretti, Alberto, Maderna, Luca, Messina, Stefano, Weiland, Ulrike, Marklund, Stefan L., Andersen, Peter M.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2017
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518287/
https://ncbi.nlm.nih.gov/pubmed/28480639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24950
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