Pyrimethamine significantly lowers cerebrospinal fluid Cu/Zn superoxide dismutase in amyotrophic lateral sclerosis patients with SOD1 mutations

OBJECTIVE: Cu/Zn superoxide dismutase (SOD1) reduction prolongs survival in SOD1‐transgenic animal models. Pyrimethamine produces dose‐dependent SOD1 reduction in cell culture systems. A previous phase 1 trial showed pyrimethamine lowers SOD1 levels in leukocytes in patients with SOD1 mutations. Thi...

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Detalhes bibliográficos
Publicado no:Ann Neurol
Main Authors: Lange, Dale J., Shahbazi, Mona, Silani, Vincenzo, Ludolph, Albert C., Weishaupt, Jochen H., Ajroud‐Driss, Senda, Fields, Kara G., Remanan, Rahul, Appel, Stanley H., Morelli, Claudia, Doretti, Alberto, Maderna, Luca, Messina, Stefano, Weiland, Ulrike, Marklund, Stefan L., Andersen, Peter M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518287/
https://ncbi.nlm.nih.gov/pubmed/28480639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24950
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