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Honokiol inhibits c-Met-HO-1 tumor-promoting pathway and its cross-talk with calcineurin inhibitor-mediated renal cancer growth

Honokiol (HNK) is a small molecule with potent anti-inflammatory and anti-tumorigenic properties; yet the molecular targets of HNK are not well studied. Hyperactivation of the receptor tyrosine kinase c-Met and overexpression of the cytoprotective enzyme heme oxygenase-1 (HO-1) play a critical role...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Balan, Murugabaskar, Chakraborty, Samik, Flynn, Evelyn, Zurakowski, David, Pal, Soumitro
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5517643/
https://ncbi.nlm.nih.gov/pubmed/28724911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05455-1
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