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The Generalized Higher Criticism for Testing SNP-Set Effects in Genetic Association Studies

It is of substantial interest to study the effects of genes, genetic pathways, and networks on the risk of complex diseases. These genetic constructs each contain multiple SNPs, which are often correlated and function jointly, and might be large in number. However, only a sparse subset of SNPs in a...

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Pubblicato in:J Am Stat Assoc
Autori principali: Barnett, Ian, Mukherjee, Rajarshi, Lin, Xihong
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5517103/
https://ncbi.nlm.nih.gov/pubmed/28736464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/01621459.2016.1192039
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