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Decreased Homodimerization and Increased TIMP-1 Complexation of Uteroplacental and Uterine Arterial Matrix Metalloproteinase-9 during Hypertension-in-Pregnancy

Preeclampsia is a complication of pregnancy manifested as hypertension-in-pregnancy (HTN-Preg) and often intrauterine growth restriction (IUGR). Placental ischemia could be an initiating event, but the molecular mechanisms are unclear. To test the hypothesis that dimerization of matrix metalloprotei...

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Publicat a:Biochem Pharmacol
Autors principals: Chen, Juanjuan, Ren, Zongli, Zhu, Minglin, Khalil, Raouf A.
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5516730/
https://ncbi.nlm.nih.gov/pubmed/28506758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2017.05.005
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