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Hindered cytoplasmic diffusion of inositol trisphosphate restricts its cellular range of action

The range of action of intracellular messengers is determined by their rates of diffusion and degradation. Previous measurements in oocyte cytoplasmic extracts indicated that the Ca(2+)-liberating second messenger inositol trisphosphate (IP(3)) diffuses with a coefficient (~280 μm(2) s(−1)) similar...

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Foilsithe in:Sci Signal
Main Authors: Dickinson, George D., Ellefsen, Kyle L., Dawson, Silvina Ponce, Pearson, John E., Parker, Ian
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5516629/
https://ncbi.nlm.nih.gov/pubmed/27919026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aag1625
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