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Hindered cytoplasmic diffusion of inositol trisphosphate restricts its cellular range of action

The range of action of intracellular messengers is determined by their rates of diffusion and degradation. Previous measurements in oocyte cytoplasmic extracts indicated that the Ca(2+)-liberating second messenger inositol trisphosphate (IP(3)) diffuses with a coefficient (~280 μm(2) s(−1)) similar...

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Vydáno v:Sci Signal
Hlavní autoři: Dickinson, George D., Ellefsen, Kyle L., Dawson, Silvina Ponce, Pearson, John E., Parker, Ian
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5516629/
https://ncbi.nlm.nih.gov/pubmed/27919026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aag1625
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