Glycan shield and epitope masking of a coronavirus spike protein observed by cryo-electron microscopy

The threat of a major coronavirus pandemic urges the development of strategies to combat these pathogens. Human coronavirus NL63 (HCoV-NL63) is an α-coronavirus that can cause severe lower-respiratory-tract infections requiring hospitalization. We report here the 3.4-Å-resolution cryo-EM reconstruct...

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Publicat a:Nat Struct Mol Biol
Autors principals: Walls, Alexandra C, Tortorici, M Alejandra, Frenz, Brandon, Snijder, Joost, Li, Wentao, Rey, Félix A, DiMaio, Frank, Bosch, Berend-Jan, Veesler, David
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group US 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5515730/
https://ncbi.nlm.nih.gov/pubmed/27617430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3293
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