Inactivation of TGFβ signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome

Specific inactivation of TGFβ signaling in neural crest stem cells (NCSCs) results in cardiovascular defects and thymic, parathyroid, and craniofacial anomalies. All these malformations characterize DiGeorge syndrome, the most common microdeletion syndrome in humans. Consistent with a role of TGFβ i...

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Bibliografiska uppgifter
Huvudupphovsmän: Wurdak, Heiko, Ittner, Lars M., Lang, Karl S., Leveen, Per, Suter, Ueli, Fischer, Jan A., Karlsson, Stefan, Born, Walter, Sommer, Lukas
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2005
Ämnen:
Research Communications
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC551573/
https://ncbi.nlm.nih.gov/pubmed/15741317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.317405
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