Inactivation of TGFβ signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome

Specific inactivation of TGFβ signaling in neural crest stem cells (NCSCs) results in cardiovascular defects and thymic, parathyroid, and craniofacial anomalies. All these malformations characterize DiGeorge syndrome, the most common microdeletion syndrome in humans. Consistent with a role of TGFβ i...

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Detalhes bibliográficos
Main Authors: Wurdak, Heiko, Ittner, Lars M., Lang, Karl S., Leveen, Per, Suter, Ueli, Fischer, Jan A., Karlsson, Stefan, Born, Walter, Sommer, Lukas
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2005
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC551573/
https://ncbi.nlm.nih.gov/pubmed/15741317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.317405
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