Inactivation of TGFβ signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome

Specific inactivation of TGFβ signaling in neural crest stem cells (NCSCs) results in cardiovascular defects and thymic, parathyroid, and craniofacial anomalies. All these malformations characterize DiGeorge syndrome, the most common microdeletion syndrome in humans. Consistent with a role of TGFβ i...

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Main Authors: Wurdak, Heiko, Ittner, Lars M., Lang, Karl S., Leveen, Per, Suter, Ueli, Fischer, Jan A., Karlsson, Stefan, Born, Walter, Sommer, Lukas
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2005
Fag:
Research Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC551573/
https://ncbi.nlm.nih.gov/pubmed/15741317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.317405
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