Metformin effects on head and neck squamous carcinoma microenvironment: Window of opportunity trial

OBJECTIVE: The tumor microenvironment frequently displays abnormal cellular metabolism, which contributes to aggressive behavior. Metformin inhibits mitochondrial oxidative phosphorylation, altering metabolism. Though the mechanism is unclear, epidemiologic studies show an association between metfor...

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Detalhes bibliográficos
Publicado no:Laryngoscope
Main Authors: Curry, Joseph, Johnson, Jennifer, Tassone, Patrick, Vidal, Marina Domingo, Menezes, Diana Whitaker, Sprandio, John, Mollaee, Mehri, Cotzia, Paolo, Birbe, Ruth, Lin, Zhao, Gill, Kurren, Duddy, Elizabeth, Zhan, Tingting, Leiby, Benjamin, Reyzer, Michelle, Cognetti, David, Luginbuhl, Adam, Tuluc, Madalina, Martinez‐Outschoorn, Ubaldo
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Head and Neck
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5515672/
https://ncbi.nlm.nih.gov/pubmed/28185288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/lary.26489
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