Metformin effects on head and neck squamous carcinoma microenvironment: Window of opportunity trial

OBJECTIVE: The tumor microenvironment frequently displays abnormal cellular metabolism, which contributes to aggressive behavior. Metformin inhibits mitochondrial oxidative phosphorylation, altering metabolism. Though the mechanism is unclear, epidemiologic studies show an association between metfor...

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Publicado en:Laryngoscope
Main Authors: Curry, Joseph, Johnson, Jennifer, Tassone, Patrick, Vidal, Marina Domingo, Menezes, Diana Whitaker, Sprandio, John, Mollaee, Mehri, Cotzia, Paolo, Birbe, Ruth, Lin, Zhao, Gill, Kurren, Duddy, Elizabeth, Zhan, Tingting, Leiby, Benjamin, Reyzer, Michelle, Cognetti, David, Luginbuhl, Adam, Tuluc, Madalina, Martinez‐Outschoorn, Ubaldo
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2017
Assuntos:
Head and Neck
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5515672/
https://ncbi.nlm.nih.gov/pubmed/28185288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/lary.26489
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