Metformin Clinical Trial in HPV+ and HPV– Head and Neck Squamous Cell Carcinoma: Impact on Cancer Cell Apoptosis and Immune Infiltrate

Background: Metformin, an oral anti-hyperglycemic drug which inhibits mitochondrial complex I and oxidative phosphorylation has been reported to correlate with improved outcomes in head and neck squamous cell carcinoma (HNSCC) and other cancers. This effect is postulated to occur through disruption...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Curry, Joseph M., Johnson, Jennifer, Mollaee, Mehri, Tassone, Patrick, Amin, Dev, Knops, Alexander, Whitaker-Menezes, Diana, Mahoney, My G., South, Andrew, Rodeck, Ulrich, Zhan, Tingting, Harshyne, Larry, Philp, Nancy, Luginbuhl, Adam, Cognetti, David, Tuluc, Madalina, Martinez-Outschoorn, Ubaldo
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6193523/
https://ncbi.nlm.nih.gov/pubmed/30364350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2018.00436
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