Longevity is impacted by growth hormone action during early postnatal period

Life-long lack of growth hormone (GH) action can produce remarkable extension of longevity in mice. Here we report that GH treatment limited to a few weeks during development influences the lifespan of long-lived Ames dwarf and normal littermate control mice in a genotype and sex-specific manner. St...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Sun, Liou Y, Fang, Yimin, Patki, Amit, Koopman, Jacob JE, Allison, David B, Hill, Cristal M, Masternak, Michal M, Darcy, Justin, Wang, Jian, McFadden, Samuel, Bartke, Andrzej
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2017
Fag:
Developmental Biology and Stem Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5515575/
https://ncbi.nlm.nih.gov/pubmed/28675141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.24059
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