Long‐lived hypopituitary Ames dwarf mice are resistant to the detrimental effects of high‐fat diet on metabolic function and energy expenditure

Growth hormone (GH) signaling stimulates the production of IGF‐1; however, increased GH signaling may induce insulin resistance and can reduce life expectancy in both mice and humans. Interestingly, disruption of GH signaling by reducing plasma GH levels significantly improves health span and extend...

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Опубликовано в: :Aging Cell
Главные авторы: Hill, Cristal M., Fang, Yimin, Miquet, Johanna G., Sun, Liou Y., Masternak, Michal M., Bartke, Andrzej
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2016
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Original Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854906/
https://ncbi.nlm.nih.gov/pubmed/26990883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12467
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