Long‐lived hypopituitary Ames dwarf mice are resistant to the detrimental effects of high‐fat diet on metabolic function and energy expenditure

Growth hormone (GH) signaling stimulates the production of IGF‐1; however, increased GH signaling may induce insulin resistance and can reduce life expectancy in both mice and humans. Interestingly, disruption of GH signaling by reducing plasma GH levels significantly improves health span and extend...

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Bibliografiska uppgifter
I publikationen:Aging Cell
Huvudupphovsmän: Hill, Cristal M., Fang, Yimin, Miquet, Johanna G., Sun, Liou Y., Masternak, Michal M., Bartke, Andrzej
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2016
Ämnen:
Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854906/
https://ncbi.nlm.nih.gov/pubmed/26990883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12467
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