Gene-modified NK-92MI cells expressing a chimeric CD16-BB-ζ or CD64-BB-ζ receptor exhibit enhanced cancer-killing ability in combination with therapeutic antibody

Natural killer (NK) cells play a pivotal role in monoclonal antibody-mediated immunotherapy through the antibody-dependent cell-mediated cytotoxicity (ADCC) mechanism. NK-92MI is an interleukin-2 (IL-2)-independent cell line, which was derived from NK-92 cells with superior cytotoxicity toward a wid...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Chen, Ying, You, Fengtao, Jiang, Licui, Li, Jialu, Zhu, Xuejun, Bao, Yangyi, Sun, Xiang, Tang, Xiaowen, Meng, Huimin, An, Gangli, Zhang, Bozhen, Yang, Lin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5514896/
https://ncbi.nlm.nih.gov/pubmed/28415754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16201
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