Nucleotide-dependent farnesyl switch orchestrates polymerization and membrane binding of human guanylate-binding protein 1

Dynamin-like proteins (DLPs) mediate various membrane fusion and fission processes within the cell, which often require the polymerization of DLPs. An IFN-inducible family of DLPs, the guanylate-binding proteins (GBPs), is involved in antimicrobial and antiviral responses within the cell. Human guan...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Shydlovskyi, Sergii, Zienert, Anke Y., Ince, Semra, Dovengerds, Christine, Hohendahl, Annika, Dargazanli, Julia M., Blum, Ailisa, Günther, Saskia D., Kladt, Nikolay, Stürzl, Michael, Schauss, Astrid C., Kutsch, Miriam, Roux, Aurélien, Praefcke, Gerrit J. K., Herrmann, Christian
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2017
Teme:
PNAS Plus
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5514708/
https://ncbi.nlm.nih.gov/pubmed/28645896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620959114
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