Nucleotide-dependent farnesyl switch orchestrates polymerization and membrane binding of human guanylate-binding protein 1

Dynamin-like proteins (DLPs) mediate various membrane fusion and fission processes within the cell, which often require the polymerization of DLPs. An IFN-inducible family of DLPs, the guanylate-binding proteins (GBPs), is involved in antimicrobial and antiviral responses within the cell. Human guan...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Shydlovskyi, Sergii, Zienert, Anke Y., Ince, Semra, Dovengerds, Christine, Hohendahl, Annika, Dargazanli, Julia M., Blum, Ailisa, Günther, Saskia D., Kladt, Nikolay, Stürzl, Michael, Schauss, Astrid C., Kutsch, Miriam, Roux, Aurélien, Praefcke, Gerrit J. K., Herrmann, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5514708/
https://ncbi.nlm.nih.gov/pubmed/28645896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620959114
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