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A dynamic pathway analysis approach reveals a limiting futile cycle in N-acetylglucosamine overproducing Bacillus subtilis

Recent advances in genome engineering have further widened the gap between our ability to implement essentially any genetic change and understanding the impact of these changes on cellular function. We lack efficient methods to diagnose limiting steps in engineered pathways. Here, we develop a gener...

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Pubblicato in:Nat Commun
Autori principali: Liu, Yanfeng, Link, Hannes, Liu, Long, Du, Guocheng, Chen, Jian, Sauer, Uwe
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512609/
https://ncbi.nlm.nih.gov/pubmed/27324299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11933
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