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A dynamic pathway analysis approach reveals a limiting futile cycle in N-acetylglucosamine overproducing Bacillus subtilis

Recent advances in genome engineering have further widened the gap between our ability to implement essentially any genetic change and understanding the impact of these changes on cellular function. We lack efficient methods to diagnose limiting steps in engineered pathways. Here, we develop a gener...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Liu, Yanfeng, Link, Hannes, Liu, Long, Du, Guocheng, Chen, Jian, Sauer, Uwe
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512609/
https://ncbi.nlm.nih.gov/pubmed/27324299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11933
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