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A dynamic pathway analysis approach reveals a limiting futile cycle in N-acetylglucosamine overproducing Bacillus subtilis

Recent advances in genome engineering have further widened the gap between our ability to implement essentially any genetic change and understanding the impact of these changes on cellular function. We lack efficient methods to diagnose limiting steps in engineered pathways. Here, we develop a gener...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Liu, Yanfeng, Link, Hannes, Liu, Long, Du, Guocheng, Chen, Jian, Sauer, Uwe
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512609/
https://ncbi.nlm.nih.gov/pubmed/27324299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11933
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