Computational design of trimeric influenza neutralizing proteins targeting the hemagglutinin receptor binding site

Many viral surface glycoproteins and cell surface receptors are homo-oligomers(1-4), and hence can potentially be targeted by geometrically matched homo-oligomers that engage all subunits simultaneously to attain high avidity and/or lock subunits together. The adaptive immune system cannot generally...

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Detalhes bibliográficos
Publicado no:Nat Biotechnol
Main Authors: Strauch, EM, Bernard, SM, La, D, Bohn, AJ, Lee, PS, Anderson, CE, Nieusma, T, Holstein, CA, Garcia, NK, Hooper, KA, Ravichandran, R, Nelson, JW, Sheffler, W, Bloom, JD, Lee, KK, Ward, AB, Yager, P, Fuller, DH, Wilson, IA, Baker, D
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512607/
https://ncbi.nlm.nih.gov/pubmed/28604661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3907
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