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Angiotensin-II Type 1 Receptor-Mediated Janus Kinase 2 Activation Induces Liver Fibrosis

Activation of the renin angiotensin system resulting in stimulation of angiotensin-II (AngII) type I receptor (AT1R) is an important factor in the development of liver fibrosis. Here, we investigated the role of Janus kinase 2 (JAK2) as a newly described intra-cellular effector of AT1R in mediating...

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Detalhes bibliográficos
Publicado no:Hepatology
Main Authors: Granzow, Michaela, Schierwagen, Robert, Klein, Sabine, Kowallick, Benita, Huss, Sebastian, Linhart, Markus, Reza Mazar, Irela G., Görtzen, Jan, Vogt, Annabelle, Schildberg, Frank A., Gonzalez-Carmona, Maria A., Wojtalla, Alexandra, Krämer, Benjamin, Nattermann, Jacob, Siegmund, Sören V., Werner, Nikos, Fürst, Dieter O., Laleman, Wim, Knolle, Percy, Shah, Vijay H., Sauerbruch, Tilman, Trebicka, Jonel
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512562/
https://ncbi.nlm.nih.gov/pubmed/24619965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27117
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