Statins activate the canonical hedgehog-signaling and aggravate non-cirrhotic portal hypertension, but inhibit the non-canonical hedgehog signaling and cirrhotic portal hypertension

Liver cirrhosis but also portal vein obstruction cause portal hypertension (PHT) and angiogenesis. This study investigated the differences of angiogenesis in cirrhotic and non-cirrhotic PHT with special emphasis on the canonical (Shh/Gli) and non-canonical (Shh/RhoA) hedgehog pathway. Cirrhotic (bil...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Uschner, Frank E., Ranabhat, Ganesh, Choi, Steve S., Granzow, Michaela, Klein, Sabine, Schierwagen, Robert, Raskopf, Esther, Gautsch, Sebastian, van der Ven, Peter F. M., Fürst, Dieter O., Strassburg, Christian P., Sauerbruch, Tilman, Mae Diehl, Anna, Trebicka, Jonel
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4585958/
https://ncbi.nlm.nih.gov/pubmed/26412302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14573
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