Statins activate the canonical hedgehog-signaling and aggravate non-cirrhotic portal hypertension, but inhibit the non-canonical hedgehog signaling and cirrhotic portal hypertension

Liver cirrhosis but also portal vein obstruction cause portal hypertension (PHT) and angiogenesis. This study investigated the differences of angiogenesis in cirrhotic and non-cirrhotic PHT with special emphasis on the canonical (Shh/Gli) and non-canonical (Shh/RhoA) hedgehog pathway. Cirrhotic (bil...

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Vydáno v:Sci Rep
Hlavní autoři: Uschner, Frank E., Ranabhat, Ganesh, Choi, Steve S., Granzow, Michaela, Klein, Sabine, Schierwagen, Robert, Raskopf, Esther, Gautsch, Sebastian, van der Ven, Peter F. M., Fürst, Dieter O., Strassburg, Christian P., Sauerbruch, Tilman, Mae Diehl, Anna, Trebicka, Jonel
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4585958/
https://ncbi.nlm.nih.gov/pubmed/26412302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14573
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