Serum markers of the extracellular matrix remodeling reflect antifibrotic therapy in bile-duct ligated rats

Background: Progression of liver fibrosis is characterized by synthesis and degradation of extracellular matrix (ECM). Matrix-metalloproteinases (MMP) cleave collagen fibers at a specific site and thereby generate soluble fragments of ECM (neo-epitopes). The levels of these neo-epitopes might reflec...

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Bibliographic Details
Main Authors: Schierwagen, Robert, Leeming, Diana J., Klein, Sabine, Granzow, Michaela, Nielsen, Mette J., Sauerbruch, Tilman, Krag, Aleksander, Karsdal, Morten A., Trebicka, Jonel
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2013
Subjects:
Physiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726835/
https://ncbi.nlm.nih.gov/pubmed/23908632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2013.00195
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