Hepatocyte ABCA1 deletion impairs liver insulin signaling and lipogenesis

Plasma membrane (PM) free cholesterol (FC) is emerging as an important modulator of signal transduction. Here, we show that hepatocyte-specific knockout (HSKO) of the cellular FC exporter, ATP binding cassette transporter A1 (ABCA1), leads to decreased PM FC content and defective trafficking of lyso...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Key, Chia-Chi C., Liu, Mingxia, Kurtz, C. Lisa, Chung, Soonkyu, Boudyguina, Elena, Dinh, Timothy A., Bashore, Alexander, Phelan, Peter E., Freedman, Barry I., Osborne, Timothy F., Zhu, Xuewei, Ma, Lijun, Sethupathy, Praveen, Biddinger, Sudha B., Parks, John S.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512440/
https://ncbi.nlm.nih.gov/pubmed/28591582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.05.032
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