Targeted deletion of hepatocyte Abca1 increases plasma HDL reverse cholesterol transport via the LDL receptor

OBJECTIVE: The role of hepatocyte ATP binding cassette transporter A1 (Abca1) in trafficking hepatic free cholesterol (FC) into plasma versus bile for reverse cholesterol transport (RCT) is poorly understood. We hypothesized that hepatocyte Abca1 recycles plasma HDL cholesterol (HDL-C) taken up by t...

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Detalhes bibliográficos
Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Bashore, Alexander C., Liu, Mingxia, Key, Chia-Chi C., Boudyguina, Elena, Wang, Xianfeng, Carroll, Caitlin M., Sawyer, Janet K., Mullick, Adam E., Lee, Richard G., Macauley, Shannon L., Parks, John S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6703909/
https://ncbi.nlm.nih.gov/pubmed/31167565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.119.312382
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