Targeted deletion of hepatocyte Abca1 increases plasma HDL reverse cholesterol transport via the LDL receptor

OBJECTIVE: The role of hepatocyte ATP binding cassette transporter A1 (Abca1) in trafficking hepatic free cholesterol (FC) into plasma versus bile for reverse cholesterol transport (RCT) is poorly understood. We hypothesized that hepatocyte Abca1 recycles plasma HDL cholesterol (HDL-C) taken up by t...

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Publicado en:Arterioscler Thromb Vasc Biol
Autores principales: Bashore, Alexander C., Liu, Mingxia, Key, Chia-Chi C., Boudyguina, Elena, Wang, Xianfeng, Carroll, Caitlin M., Sawyer, Janet K., Mullick, Adam E., Lee, Richard G., Macauley, Shannon L., Parks, John S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6703909/
https://ncbi.nlm.nih.gov/pubmed/31167565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.119.312382
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