Hepatocyte ABCA1 deletion impairs liver insulin signaling and lipogenesis

Plasma membrane (PM) free cholesterol (FC) is emerging as an important modulator of signal transduction. Here, we show that hepatocyte-specific knockout (HSKO) of the cellular FC exporter, ATP binding cassette transporter A1 (ABCA1), leads to decreased PM FC content and defective trafficking of lyso...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Key, Chia-Chi C., Liu, Mingxia, Kurtz, C. Lisa, Chung, Soonkyu, Boudyguina, Elena, Dinh, Timothy A., Bashore, Alexander, Phelan, Peter E., Freedman, Barry I., Osborne, Timothy F., Zhu, Xuewei, Ma, Lijun, Sethupathy, Praveen, Biddinger, Sudha B., Parks, John S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512440/
https://ncbi.nlm.nih.gov/pubmed/28591582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.05.032
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