Development of Clade-Specific and Broadly Reactive Live Attenuated Influenza Virus Vaccines against Rapidly Evolving H5 Subtype Viruses

We have developed pandemic live attenuated influenza vaccines (pLAIVs) against clade 1 H5N1 viruses on an Ann Arbor cold-adapted (ca) backbone that induced long-term immune memory. In 2015, many human infections caused by a new clade (clade 2.2.1.1) of goose/Guangdong (gs/GD) lineage H5N1 viruses we...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Boonnak, Kobporn, Matsuoka, Yumiko, Wang, Weijia, Suguitan, Amorsolo L., Chen, Zhongying, Paskel, Myeisha, Baz, Mariana, Moore, Ian, Jin, Hong, Subbarao, Kanta
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2017
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512263/
https://ncbi.nlm.nih.gov/pubmed/28490598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00547-17
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