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Deletion of the Vaccinia Virus B1 Kinase Reveals Essential Functions of This Enzyme Complemented Partly by the Homologous Cellular Kinase VRK2

The vaccinia virus B1 kinase is highly conserved among poxviruses and is essential for the viral life cycle. B1 exhibits a remarkable degree of similarity to vaccinia virus-related kinases (VRKs), a family of cellular kinases, suggesting that the viral enzyme has evolved to mimic VRK activity. Indee...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Olson, Annabel T., Rico, Amber B., Wang, Zhigang, Delhon, Gustavo, Wiebe, Matthew S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512240/
https://ncbi.nlm.nih.gov/pubmed/28515294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00635-17
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