The Vaccinia Virus B12 Pseudokinase Represses Viral Replication via Interaction with the Cellular Kinase VRK1 and Activation of the Antiviral Effector BAF

The poxviral B1 and B12 proteins are a homologous kinase-pseudokinase pair, which modulates a shared host pathway governing viral DNA replication and antiviral defense. While the molecular mechanisms involved are incompletely understood, B1 and B12 seem to intersect with signaling processes mediated...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Rico, Amber B., Linville, Alexandria C., Olson, Annabel T., Wang, Zhigang, Wiebe, Matthew S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7925102/
https://ncbi.nlm.nih.gov/pubmed/33177193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02114-20
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