Antileishmanial activity and tubulin polymerization inhibition of podophyllotoxin derivatives on Leishmania infantum

Leishmania microtubules play an important role not only in cell division, but also in keeping the shape of the parasite and motility of its free-living stages. Microtubules result from the self-assembly of alpha and beta tubulins, two phylogenetically conserved and very abundant eukaryotic proteins...

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Vydáno v:Int J Parasitol Drugs Drug Resist
Hlavní autoři: Escudero-Martínez, José Miguel, Pérez-Pertejo, Yolanda, Reguera, Rosa M., Castro, María Ángeles, Rojo, María Victoria, Santiago, Carolina, Abad, Andrés, García, Pablo Anselmo, López-Pérez, José Luis, San Feliciano, Arturo, Balaña-Fouce, Rafael
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512185/
https://ncbi.nlm.nih.gov/pubmed/28719882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2017.06.003
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