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Structural insights into the mycobacteria transcription initiation complex from analysis of X-ray crystal structures

The mycobacteria RNA polymerase (RNAP) is a target for antimicrobials against tuberculosis, motivating structure/function studies. Here we report a 3.2 Å-resolution crystal structure of a Mycobacterium smegmatis (Msm) open promoter complex (RPo), along with structural analysis of the Msm RPo and a p...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Hubin, Elizabeth A., Lilic, Mirjana, Darst, Seth A., Campbell, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5511352/
https://ncbi.nlm.nih.gov/pubmed/28703128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms16072
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