Role of insulin receptor substrates in the progression of hepatocellular carcinoma

Several cellular signaling pathways, including insulin/IGF signaling, are known to be activated in hepatocellular carcinoma (HCC). Here, we investigated the roles of insulin receptor substrate (Irs) 1 and Irs2, both of which are the major molecules to be responsible for transducing insulin/IGF signa...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Sakurai, Yoshitaka, Kubota, Naoto, Takamoto, Iseki, Obata, Atsushi, Iwamoto, Masahiko, Hayashi, Takanori, Aihara, Masakazu, Kubota, Tetsuya, Nishihara, Hiroshi, Kadowaki, Takashi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5511151/
https://ncbi.nlm.nih.gov/pubmed/28710407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03299-3
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