Cryopreservation Maintains Functionality of Human iPSC Dopamine Neurons and Rescues Parkinsonian Phenotypes In Vivo

A major challenge for clinical application of pluripotent stem cell therapy for Parkinson's disease (PD) is large-scale manufacturing and cryopreservation of neurons that can be efficiently prepared with minimal manipulation. To address this obstacle, midbrain dopamine neurons were derived from...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Wakeman, Dustin R., Hiller, Benjamin M., Marmion, David J., McMahon, Christopher W., Corbett, Grant T., Mangan, Kile P., Ma, Junyi, Little, Lauren E., Xie, Zhong, Perez-Rosello, Tamara, Guzman, Jaime N., Surmeier, D. James, Kordower, Jeffrey H.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5511045/
https://ncbi.nlm.nih.gov/pubmed/28579395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.04.033
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