A bosentan pharmacokinetic study to investigate dosing regimens in paediatric patients with pulmonary arterial hypertension: FUTURE‐3

AIM: The aim of the present study was to investigate whether increasing the bosentan dosing frequency from 2 mg kg(–1) twice daily (b.i.d.) to 2 mg kg(–1) three times daily (t.i.d.) in children with pulmonary arterial hypertension (PAH) (from ≥3 months to <12 years of age) would increase exposure...

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Vydáno v:Br J Clin Pharmacol
Hlavní autoři: Berger, Rolf M. F., Gehin, Martine, Beghetti, Maurice, Ivy, Dunbar, Kusic‐Pajic, Andjela, Cornelisse, Peter, Grill, Simon, Bonnet, Damien
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
Pharmacokinetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510076/
https://ncbi.nlm.nih.gov/pubmed/28213957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13267
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