Phosphorylation of Argonaute proteins affects mRNA binding and is essential for microRNA‐guided gene silencing in vivo

Argonaute proteins associate with microRNAs and are key components of gene silencing pathways. With such a pivotal role, these proteins represent ideal targets for regulatory post‐translational modifications. Using quantitative mass spectrometry, we find that a C‐terminal serine/threonine cluster is...

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Pubblicato in:EMBO J
Autori principali: Quévillon Huberdeau, Miguel, Zeitler, Daniela M, Hauptmann, Judith, Bruckmann, Astrid, Fressigné, Lucile, Danner, Johannes, Piquet, Sandra, Strieder, Nicholas, Engelmann, Julia C, Jannot, Guillaume, Deutzmann, Rainer, Simard, Martin J, Meister, Gunter
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2017
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510005/
https://ncbi.nlm.nih.gov/pubmed/28645918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201696386
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