Phosphorylation of Argonaute proteins affects mRNA binding and is essential for microRNA‐guided gene silencing in vivo

Argonaute proteins associate with microRNAs and are key components of gene silencing pathways. With such a pivotal role, these proteins represent ideal targets for regulatory post‐translational modifications. Using quantitative mass spectrometry, we find that a C‐terminal serine/threonine cluster is...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:EMBO J
Prif Awduron: Quévillon Huberdeau, Miguel, Zeitler, Daniela M, Hauptmann, Judith, Bruckmann, Astrid, Fressigné, Lucile, Danner, Johannes, Piquet, Sandra, Strieder, Nicholas, Engelmann, Julia C, Jannot, Guillaume, Deutzmann, Rainer, Simard, Martin J, Meister, Gunter
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2017
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510005/
https://ncbi.nlm.nih.gov/pubmed/28645918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201696386
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