Phosphorylation of Argonaute proteins affects mRNA binding and is essential for microRNA‐guided gene silencing in vivo

Argonaute proteins associate with microRNAs and are key components of gene silencing pathways. With such a pivotal role, these proteins represent ideal targets for regulatory post‐translational modifications. Using quantitative mass spectrometry, we find that a C‐terminal serine/threonine cluster is...

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Vydáno v:EMBO J
Hlavní autoři: Quévillon Huberdeau, Miguel, Zeitler, Daniela M, Hauptmann, Judith, Bruckmann, Astrid, Fressigné, Lucile, Danner, Johannes, Piquet, Sandra, Strieder, Nicholas, Engelmann, Julia C, Jannot, Guillaume, Deutzmann, Rainer, Simard, Martin J, Meister, Gunter
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510005/
https://ncbi.nlm.nih.gov/pubmed/28645918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201696386
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