Phosphorylation of Argonaute proteins affects mRNA binding and is essential for microRNA‐guided gene silencing in vivo

Argonaute proteins associate with microRNAs and are key components of gene silencing pathways. With such a pivotal role, these proteins represent ideal targets for regulatory post‐translational modifications. Using quantitative mass spectrometry, we find that a C‐terminal serine/threonine cluster is...

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Bibliografski detalji
Izdano u:EMBO J
Glavni autori: Quévillon Huberdeau, Miguel, Zeitler, Daniela M, Hauptmann, Judith, Bruckmann, Astrid, Fressigné, Lucile, Danner, Johannes, Piquet, Sandra, Strieder, Nicholas, Engelmann, Julia C, Jannot, Guillaume, Deutzmann, Rainer, Simard, Martin J, Meister, Gunter
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
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Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510005/
https://ncbi.nlm.nih.gov/pubmed/28645918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201696386
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