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Hepatic MDR3 expression impacts lipid homeostasis and susceptibility to inflammatory bile duct obstruction in neonates

BACKGROUND: Heterozygous mutations in the gene ABCB4, encoding the phospholipid floppase MDR3 (Mdr2 in mice), are associated with various chronic liver diseases. Here, we hypothesize that reduced ABCB4 expression predisposes to extrahepatic biliary atresia (EHBA). METHODS: Livers from neonatal wildt...

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Vydáno v:	Pediatr Res
Hlavní autoři:	Carey, Alexandra N., Zhang, Wujuan, Setchell, Kenneth D.R., Simmons, Julia E., Shi, Tiffany, Lages, Celine S., Mullen, Mary, Carroll, Kaitlin, Karns, Rebekah, Bessho, Kazuhiko, Sheridan, Rachel, Zhao, Xueheng, Weber, Susanne N., Miethke, Alexander G.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	2017
Témata:	Article
On-line přístup:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5509537/ https://ncbi.nlm.nih.gov/pubmed/28355206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pr.2017.78
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Hepatic MDR3 expression impacts lipid homeostasis and susceptibility to inflammatory bile duct obstruction in neonates

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