Hepatic MDR3 expression impacts lipid homeostasis and susceptibility to inflammatory bile duct obstruction in neonates

BACKGROUND: Heterozygous mutations in the gene ABCB4, encoding the phospholipid floppase MDR3 (Mdr2 in mice), are associated with various chronic liver diseases. Here, we hypothesize that reduced ABCB4 expression predisposes to extrahepatic biliary atresia (EHBA). METHODS: Livers from neonatal wildt...

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Pubblicato in:Pediatr Res
Autori principali: Carey, Alexandra N., Zhang, Wujuan, Setchell, Kenneth D.R., Simmons, Julia E., Shi, Tiffany, Lages, Celine S., Mullen, Mary, Carroll, Kaitlin, Karns, Rebekah, Bessho, Kazuhiko, Sheridan, Rachel, Zhao, Xueheng, Weber, Susanne N., Miethke, Alexander G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509537/
https://ncbi.nlm.nih.gov/pubmed/28355206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pr.2017.78
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