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PTCH1 is a reliable marker for predicting imatinib response in chronic myeloid leukemia patients in chronic phase

Patched homolog 1 gene (PTCH1) expression and the ratio of PTCH1 to Smoothened (SMO) expression have been proposed as prognostic markers of the response of chronic myeloid leukemia (CML) patients to imatinib. We compared these measurements in a realistic cohort of 101 patients with CML in chronic ph...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Alonso-Dominguez, Juan M., Casado, Luis Felipe, Anguita, Eduardo, Gomez-Casares, Maria Teresa, Buño, Ismael, Ferrer-Marín, Francisca, Arenas, Alicia, Del Orbe, Rafael, Ayala, Rosa, Llamas, Pilar, Salgado, Rocio N., Osorio, Santiago, Sanchez-Godoy, Pedro, Burgaleta, Carmen, Mahíllo-Fernández, Ignacio, Garcia-Gutierrez, Valentin, Steegmann, Juan Luis, Martinez-Lopez, Joaquín
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509313/
https://ncbi.nlm.nih.gov/pubmed/28704552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0181366
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