BNIP3 induction by hypoxia stimulates FASN-dependent free fatty acid production enhancing therapeutic potential of umbilical cord blood-derived human mesenchymal stem cells

Mitophagy under hypoxia is an important factor for maintaining and regulating stem cell functions. We previously demonstrated that fatty acid synthase (FASN) induced by hypoxia is a critical lipid metabolic factor determining the therapeutic efficacy of umbilical cord blood-derived human mesenchymal...

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Pubblicato in:Redox Biol
Autori principali: Lee, Hyun Jik, Jung, Young Hyun, Choi, Gee Euhn, Ko, So Hee, Lee, Sei-Jung, Lee, Sang Hun, Han, Ho Jae
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2017
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5508529/
https://ncbi.nlm.nih.gov/pubmed/28704726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.07.004
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